Preheat oven to 375ºF and grease a muffin pan.
In a bowl, combine ground beef, chopped onion, minced garlic, egg, pork panko, cheddar cheese, oregano, salt & pepper and knead together until well combined.
Shape ¼ cup of the meat mixture into a puck shape and place it into the muffin pan. Should make about 11 mini meatloaves.
Top each mini meatloaf with ½ tablespoon of ketchup.
Bake for about 20-25 minutes, or until the muffins are cooked through and have an internal temperature of 160°F (71°C).